The African Center for Policy and Advocacy focuses on four cross-cutting strategic issues: Good Governance, Education, Health, and Climate. These interconnected challenges impact youth, women, and other vulnerable populations and require multi-sectoral collaboration. Strengthening governance frameworks is essential to ensuring transparency, accountability, and inclusive decision-making in addressing health disparities, educational access, and climate resilience. Tackling these issues demands evidence-based interventions, awareness-raising, capacity-building, and a supportive policy environment for sustainable change.